Public health & disease

From disease eradication efforts to advances in vaccination and maternal health, this archive tracks real progress in public health. Stories here focus on what’s working — policies, interventions, and research that are improving and extending lives around the world.

Measuring Psilocybin Magic Mushroom Micro Doses in Laboratory for A Scientific Experiment, for article on psilocybin therapy

The world’s first Phase 3 psilocybin clinical trial is about to commence

Psilocybin therapy is making history: Compass Pathways will launch the world’s first Phase 3 trial for treatment-resistant depression by the end of 2022, enrolling nearly 1,000 participants across two pivotal studies. This is the threshold every promising drug must cross to become an approved medicine, and no psychedelic compound has crossed it before. For the roughly 100 million people worldwide whose depression doesn’t respond to standard treatments, the stakes are real — current options are few, often invasive, and inconsistently helpful. A single guided dose, if the evidence holds, could reshape what care looks like. Beyond depression, this moment signals that a long-stigmatized class of medicines is finally being tested with the rigor patients deserve.

Good news for public health, for article on CAB-LA HIV prevention, for article on lenacapavir HIV prevention, for article on HIV infections in young men

Zimbabwe becomes first African nation to approve HIV prevention drug

Zimbabwe just became the first country in Africa to approve cabotegravir, a long-acting HIV prevention injection given once every two months — joining only Australia and the United States. For young women and girls especially, that change is huge: a single shot replaces the daily pill regimen that stigma, privacy concerns, and patchy healthcare often make hard to sustain. It builds on a remarkable turnaround, with AIDS-related deaths in Zimbabwe falling from roughly 130,000 in 2002 to about 20,000 in 2021. As advocate Nyasha Sithole put it, ending the epidemic requires a real “basket of tools.” Zimbabwe’s quick action sends a powerful signal that African regulators don’t have to wait in line for life-saving HIV breakthroughs.