Public health & disease

Woman with pink breast cancer ribbon

New therapy trial from Australian researchers nearly doubles breast cancer cure rates

A phase 3 clinical trial from Melbourne’s Peter MacCallum Cancer Center has shown that adding a targeted immunotherapy drug to chemotherapy dramatically improved the cure rate for patients with the most common kind of breast cancer. In the present phase 3 trial, 510 patients were randomized to receive chemotherapy with either intravenous nivolumab or placebo. In patients treated with nivolumab plus chemotherapy, rates were statistically significant, nearly double those who received placebo plus chemo: 24.5% versus 13.8%, respectively.

Tbilisi, Georgia

Georgia certified malaria-free

The country of Georgia has been certified malaria-free following a nearly century-long fight to combat the disease, the World Health Organization has announced. It joins 45 countries that have achieved this milestone. Malaria has plagued Georgia since ancient times. During the post-war period, Georgia launched an intensive program focused on eliminating malaria. The campaign successfully interrupted the transmission of many strains by 1970 and the country remained malaria-free for 25 years. But by 2002 the disease had reemerged.

Landfill. A lot of plastic garbage. Environmental problems.

Thailand bans imports of plastic waste to curb toxic pollution

A law banning imports of plastic waste came into force in Thailand, after years of campaigning by activists. Thailand is one of several south-east Asian countries that has historically been paid to receive plastic waste from developed nations. Thai customs officials said more than 1.1 million tons of plastic scraps were imported between 2018 and 2021. Imports of plastic were often mismanaged, with many factories burning the waste rather than recycling it, leading to damage to human health and the environment.

Facility releasing air pollution|google

China has reduced sulphur dioxide emissions by more than two-thirds in the last 15 years

China has dramatically reduced local air pollution levels — particularly in its biggest cities — in the last decade. One rapidly declining pollutant is sulphur dioxide (SO2), which generates smog, causes ecologically-damaging acid rain, and is associated with higher rates of lung cancer and other respiratory issues. China has been able to make remarkable gains in curbing S02 emissions by putting emissions limits on coal plants and introducing desulphurization technologies that remove SO2 from smokestacks.

Depiction of intestines

“100% successful” cancer drug gets landmark U.S. FDA approval

Hugely promising cancer drug dostarlimab is one step closer to being widely available, after the U.S. Food and Drug Administration granted it Breakthrough Therapy Designation status. The drug, a programmed death receptor-1-blocking antibody, completely eradicated rectal cancer tumors without the need for surgery, radiation treatment, or chemotherapy. “Everyone on the clinical trial is doing great,” Memorial Sloan Kettering Cancer Center gastrointestinal oncologist Andrea Cercek said. “So far, 42 people have completed treatment, and all of them have no evidence of disease. Side effects were quite mild and well tolerated.”

Model lungs

Doctors hail first breakthrough in asthma and COPD treatment in 50 years

A trial from King’s College London found offering patients a new injection was more effective than the current care of steroid tablets, and cuts the need for further treatment by 30%. The results, published in the Lancet Respiratory Medicine journal, could be transformative for millions of people with asthma and COPD around the world. Lead investigator Professor Mona Bafadhel said: “This could be a gamechanger for people with asthma and COPD. Treatment for asthma and COPD exacerbations have not changed in 50 years, despite causing 3.8 million deaths worldwide a year combined.”

Ovarian and Cervical Cancer Awareness. a Teal Ribbon

Cervical cancer deaths are plummeting among young U.S. women

Every year, thousands of American women die of cervical cancer. However, from 1992 to 2015, the number of deaths due to cervical cancer among U.S. women under the age of 25 fell steadily from each three-year period to the next, dropping roughly 75% altogether over that span. The sharp decline in cervical cancer deaths is likely due, at least in part, to the widespread introduction of the HPV vaccine in 2006.

Breakthrough genomic test identifies virtually any infection in one go

Researchers at University of California San Francisco (UCSF) have developed a single genomic test that can quickly detect virtually any kind of pathogen in a patient. This allows for much quicker diagnoses, enables targeted treatment to begin sooner, and could lower healthcare costs. Over the course of 7 years, researchers led by UCSF professor Charles Chiu tested 4,828 patients’ samples with its clinical mNGS method. The mNGS test accurately identified 86% of neurological infections.

digitally colorized scanning electron microscopic (SEM) image, depicts a blue-colored, human white blood cell, (WBC) known specifically as a neutrophil, interacting with two pink-colored, rod shaped, multidrug-resistant (MDR), Klebsiella pneumoniae bacteria

Global child deaths from pneumonia have been cut in half since 2009

Pneumonia kills 2,000 children under five worldwide every day, making it the world’s biggest infectious cause of death in children. The introduction of pneumococcal conjugate vaccines (PCVs) has significantly lowered the burden of death and disease from pneumonia, but millions of children remain unvaccinated. Since the public-private global health partnership Gavi supported the first roll-out of the PCV vaccine in 2009, 438 million children of all ages have been vaccinated in 64 countries, averting an estimated total of 1.2 million deaths by the end of 2023.

Human eye up close

Japanese researchers develop world-first stem-cell treatment that restores vision in humans

Kohji Nishida, an ophthalmologist at Osaka University in Japan, and his colleagues used an alternative source of cells — induced pluripotent stem (iPS) cells — to make the corneal transplants. They took blood cells from a healthy donor and reprogrammed them into an embryonic-like state, then transformed them into a thin, transparent sheet of cobblestone-shaped corneal epithelial cells. After the transplants, all four recipients showed immediate improvements in their vision and a reduction in the area of the cornea affected by limbal stem-cell deficiency. The improvements persisted in all but one recipient, who showed slight reversals during a one-year observation period.

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