Child well-being

This archive covers measurable progress in child well-being — from advances in pediatric health and early education to policies reducing child poverty and hunger. Across 129 articles, these stories highlight what is working for kids around the world and the people driving that change.

Scientist examines the result of a plaque assay, for article on gene therapy cure MLD

Researchers cure toddler of deadly metachromatic leukodystrophy (MLD) for first time in history

Gene therapy has cured 19-month-old Teddi Shaw of metachromatic leukodystrophy, making her the first NHS patient treated for this rare, fatal nervous system disease. After a single infusion of Libmeldy at Royal Manchester Children’s Hospital, she’s now running around, chattering away, and showing no signs of the illness that typically kills children before age eight. The treatment works by correcting a faulty gene in the child’s own stem cells, eliminating the disease at its root rather than managing it. Her family’s joy is tempered by grief — Teddi’s older sister was diagnosed too late for the therapy to help, fueling calls for newborn screening. It’s a glimpse of medicine’s next era: one-time cures for inherited conditions, if access and early detection can keep pace.