North & Central America

This archive covers progress stories from North and Central America, spanning the U.S., Canada, Mexico, and the nations of Central America. Readers will find reporting on health, environment, community resilience, and policy advances across the region.

Surgeons operating, for article on pig kidney xenotransplant

Pig kidney functions in human patients for two full months for first time ever

A genetically modified pig kidney kept working inside a human body for 61 days at NYU Langone Health — the longest a non-human organ has ever functioned in a person. Surgeons used a simplified approach, transplanting a kidney from a pig with just one gene edit and leaving the thymus gland attached to help the recipient’s immune system accept it. Around 100,000 Americans are on the kidney waitlist at any given time, and researchers hope pig organs could one day help close that gap. The team is now preparing for clinical trials pending FDA approval. For the thousands waiting on a kidney that may not arrive in time, this is real, tangible hope.

Pills and syringe, for article on fentanyl vaccine human trials

Scientists preparing first human trials for vaccines that block the effects of deadly opioids

Fentanyl vaccines are heading into their first human trials, with Phase 1 testing set to begin in early 2024 at Columbia University. Developed by researchers at the University of Montana and University of Washington, the vaccines train the immune system to grab fentanyl molecules in the bloodstream, like a sponge, before they can reach the brain. That means no high, and no slowed breathing, which is what makes overdoses fatal. The team is especially focused on people in the first two years of recovery, when relapse risk is highest. If it works, this could become a powerful new tool in a crisis that has demanded every bit of compassion and ingenuity we can offer.