Colorado’s Natural Medicine Health Act goes further than any previous U.S. state psychedelic law, removing criminal penalties for personal use of psilocybin, DMT, ibogaine, and mescaline — and building a licensed therapy clinic system alongside it. The FDA has already granted psilocybin “breakthrough therapy” status for treatment-resistant depression, giving this reform unusual clinical credibility. Colorado helped pioneer cannabis legalization in 2012, and advocates are watching to see whether psychedelic reform follows a similar path outward. For people who haven’t found relief through conventional treatments, this law opens a genuinely new door.