Science & academia

Good news for public health

U.S. Food & Drug Administration approves world’s first 100% effective HIV prevention drug

By / / Good News For Humankind

The U.S. FDA has approved lenacapavir (Yeztugo), the first HIV prevention shot that’s given just twice a year. In large studies, it was virtually 100% effective—no HIV cases were seen in one trial, and only two cases occurred in another with more than 2,000 people. This long-lasting protection could make it much easier for people to stay protected, especially for those who find taking a daily pill difficult. By reducing the need for frequent dosing, the new treatment has the potential to greatly expand access to HIV prevention and help move the world closer to ending the deadly epidemic that has killed more than 44 million people worldwide since 1981.

Holding hands

Pancreatic cancer vaccine eradicates deadly disease in more than half of targets in early trials

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The pioneering work from Cleveland’s Case Western Reserve University researchers targets pancreatic ductal adenocarcinoma, the most common cancer that plagues the organ. While not the most common form of cancer, pancreatic cancer is particularly insidious, often remaining undetected until it metastasizes. The five-year survival rate is just 13.3%. In preclinical trials, the vaccine eliminated the cancer in more than half of the targets.

Depiction of viruses

Breakthrough in search for HIV cure leaves Australian researchers ‘overwhelmed’

By / / Good News For Humankind

The virus’s ability to conceal itself inside white blood cells is a core challenge for scientists looking for a cure. It means there is a reservoir of HIV in the body, capable of reactivation, that neither the immune system nor drugs can access. Now, researchers from the Peter Doherty Institute for Infection & Immunity in Melbourne have found a way to make the virus visible, paving the way to fully clear it from the body. UNAids estimates that one person died of HIV every minute in 2023.

Illustration of red blood cells

Japan to begin clinical trials for artificial blood

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For decades, a shrinking population and an aging society in Japan have led to fewer blood donors. This situation is especially dire during disasters or in remote regions, where matching blood types and storing donated blood are logistical nightmares. Recognizing this, researchers at Nara Medical University are developing a safe, effective artificial blood that could be administered to anyone, anywhere, at any time. Clinical trials begin this year, with practical use expected by 2030.

Surgery

Surgeons in California perform first-ever successful bladder transplant

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Patients who have their bladder removed most often have a portion of intestine repurposed to pass urine, often resulting in a host of new complications, including infections and digestive issues. Those complications have led doctors around the world to seek bladder transplant techniques for years. The transplant performed in early May has so far succeeded, and doctors said they are “satisfied” with the patient’s recovery, though many unknowns remain.

Teal Wand - Pap smear alternative

The U.S. FDA approves first at-home tool as a Pap-smear alternative

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Traditionally, gynecologists have inserted a cold metal speculum deep into a woman’s vagina to scrape cells from the cervix. The Teal Wand — “built with empathy” by California-based Teal Health — uses a swab to collect a vaginal sample. Women will then mail the sample to a lab that will screen for HPV (human papillomavirus), the virus that causes nearly all cervical cancers. The FDA approval follows a U.S.-based study that found at-home screening was just as effective as that done in a doctor’s office.

Illustration of intestines

Fecal transplants reduce alcohol cravings as human trials progress

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Researchers at Virginia Commonwealth University have found that fecal transplants may help those suffering from severe alcohol use disorder. The work points to a compelling relationship between the gut microbiome and addiction disorders, with large-scale Phase 2 human trials currently underway. Nine of 10 patients who received a transplant had a reduction in their cravings and in the urine measurement of alcohol-related metabolites, compared to only three of the 10 placebo subjects displaying similar levels of improvement.

Illustration of brain

Psilocybe fungi are an effective treatment for repeated concussions, new study suggests

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A new study from Boston’s Northeastern University has found that “magic mushrooms” could be an effective treatment for concussions because of their brain-healing properties. Rats given the medicinal fungi post-head injury showed reduced edema and “dramatic hyperconnectivity” in parts of the brain that are pathways for dopamine. The researchers said that the hyperconnected dopaminergic pathways could indicate neuroplasticity, the ability of the brain to reorganize itself in response to injury.

Baby sea turtles in the sand

Endangered sea turtles show signs of recovery in majority of places they’re found worldwide

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Endangered sea turtles are making a comeback in many parts of the world, according to a newly published global survey from researchers at Stanford University and other institutions. The study, featured in Endangered Species Research, found that threats to the marine animals—such as hunting, pollution, and coastal development—are declining in more than half of the areas examined. Although the findings offer hope, researchers caution that not all turtle populations are rebounding equally. Leatherback turtles, in particular, remain under severe threat.

​Korean scientists develop technique that detects nearly 100% of bacterial infections in under 3 hours​

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Scientists at the Ulsan National Institute of Science & Technology (UNIST) in South Korea have made a major breakthrough in the accuracy and speed at which often deadly pathogen infections can be identified and treated. In many cases, this accelerated process can save lives. The new technique, known as fluorescence in situ hybridization (FISH), detected seven species of bacteria that commonly infect humans. It proved to be more than 99% accurate for all but one – a pathogen that infects skin tissue – which had a still-impressive 96.3% success rate.