New epilepsy drug cuts seizures by nearly 80% in mid-stage trial
Epilepsy drug RAP-219 has shown striking results in a mid-stage clinical trial, reducing seizures by a median of 77.8% in adults whose epilepsy had not responded to existing medications. Developed by Rapport Therapeutics, the drug works by precisely targeting overactive brain regions rather than broadly suppressing electrical activity across the whole brain. Nearly one in four participants became completely seizure-free during the eight-week study. The trial’s use of implanted neurostimulation devices provided objective, real-time brain data that strengthens confidence in the findings. Phase 3 trials are expected to begin in 2026.









